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It is caused by mutations in the gene of pantothenate kinase 2 (PANK2) that result in dysfunction in PANK2 enzyme activity, with consequent deficiency of coenzyme A (CoA) biosynthesis, as well as low levels of essential metabolic intermediates such as 4-phosphopantetheine, a necessary cofactor for essential cytosolic and mitochondrial proteins
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& Ortega, R
Supplemente knnen fr diese Personen essenziell sein und werden besonders fr Leute empfohlen, die eine genetische Erkrankung haben oder in einer medizinischen Behandlung sind, welche die L-Carnitin-Versorgung des Krpers aufbraucht (1)
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