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24 In addition, extensive research has demonstrated that GLP-1RAs show kidney-protective benefits in animal models of diabetic nephropathy and AKI
111 The only acceptable alternative endpoint in drug development, histological evidence, consists of the resolution of steatohepatitis and no worsening of liver fibrosis, or improvement in liver fibrosis of at least one stage without worsening of steatohepatitis
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Most of the studies that are often cited to support the use of BPC-157 are preclinical, conducted on animal models
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