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In the STEP UP trial of 1,407 adults with obesity, semaglutide 7.2 mg produced a mean weight change of 18.7% at week 72 versus 15.6% with semaglutide 2.4 mg, an estimated treatment difference of 3.1%
A state-licensed pharmacy can still compound a GLP-1 for an individual patient with a valid prescription in narrow situations for example, a documented allergy to an inactive ingredient in the approved product, a need for a different formulation, or a prescriber-documented significant clinical difference for that specific patient
Someone who may have always had food on the brain and could eat large amounts of food may become indifferent to food altogether and only be able to handle smaller portions
Critical point: returning a warm medication to the refrigerator does not undo the damage
