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It is most often chosen for overall skin radiance, an uneven complexion, and tan or melasma-related dullness
10.1089/ars.2012.4508 35
Anyone taking methyl-donor-sensitive medications (some psychiatric drugs, methotrexate, methylated B-vitamin protocols at high doses): NNMT shares the methyl donor SAM, so theoretical interactions exist
Its current replacement is pentadeca arginate (PDA), which is essentially the same molecule (same 15-amino-acid backbone), but isnt scheduled
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