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The angiogenesis promotion that makes BPC-157 potentially valuable for cardiovascular applications also raises theoretical questions
A peer-reviewed study in the Journal of Clinical Endocrinology and Metabolism confirming that CJC-1295 produces sustained, dose-dependent increases in GH and IGF-1 levels with a favorable safety profile in healthy adults
Multiple randomized controlled trials and meta-analyses in patients with type 2 diabetes and obesity demonstrate that GLP-1RA therapy either preserves or modestly increases bone mineral density (BMD) at key skeletal sites lumbar spine and hip, GLP-1RAs also favorably modulate bone turnover markers, increasing bone formation markers (P1NP, osteocalcin, bone-specific alkaline phosphatase) and reducing bone resorption markers (-CTX), suggesting a net positive or neutral effect on bone remodeling
Phase I/II study of DZD6008, a 4th-generation EGFR TKI with full BBB penetration, in EGFR-mutant NSCLC
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