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How Mounjaro works Mounjaro mimics two hormones: Like Ozempic, it activates the GLP-1 receptor It also activates a second receptor called GIP (glucose-dependent insulinotropic polypeptide) This dual-action mechanism likely explains why Mounjaro produces greater weight loss and improvements in blood sugar in clinical trials

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GIP receptor activation Glucose-dependent insulinotropic polypeptide, or GIP, was long considered a problem hormone