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Potential interactions include: Metformin (used for type 2 diabetes) Proton pump inhibitors (PPIs) and H2-receptor antagonists (used for acid reflux) Colchicine (used for gout) Nitrous oxide (anaesthetic gas that can inactivate B12) Chloramphenicol (may reduce the haematological response to B12 therapy) If you take any of these medications long-term, discuss B12 monitoring with your healthcare provider
Handbook of vitamins (Fifth ed.)
Split Dosing Strategy: Advanced Protocol For experienced users seeking sustained metabolic support, split dosing divides the daily amount into two administrations: This approach maintains more consistent plasma levels throughout the day, potentially providing smoother metabolic effects
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