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Obesity also often leads to abnormal lipid profiles, characterized by high levels of triglycerides and low levels of high-density lipoprotein (HDL) cholesterol

Evidence From Clinical Trials on Cardiovascular Outcomes Phase 2 data (NEJM 2023) showed systolic blood pressure reductions of approximately 46 mmHg and a modest heart rate increase, but no cardiovascular outcome trial exists for retatrutide and definitive conclusions about cardiovascular benefit or risk cannot yet be made

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Applying a cold compress or ice pack wrapped in a clean cloth to the injection site for 1015 minutes several times during the first few hours can promote vasoconstriction, reducing blood leakage into tissues