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Because of ubiquitination and subsequent proteolysis, Nrf2 turns over rapidly with a half-life of 715 min, which increases to 30100 min in the presence of oxidative or electrophilic stress (McMahon et al
Presented for research literature review only Agndez JA et al
Notably, patients with mutations in GGT1 often present with developmental disorders, accumulation of GSH (glutathionaemia and glutathionuria) and reduced circulating levels of cystine 25
The use of oral or topical glutathione depends on the requirements and advice of healthcare professionals
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