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Here, the method was applied in a systematic fashion to the 31 amino acid peptide GLP-1 to generate a series of GLP-1-oligourea hybrids among which potent agonists of GLP-1R were identified
While tirzepatide made history as the first dual GIP/GLP-1 receptor agonist to receive FDA approval, retatrutide pushes the pharmacological envelope further with triple receptor agonism that adds glucagon receptor activation
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