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Indications and Usage Ozempic (semaglutide) injection 0.5 mg, 1 mg, or 2 mg and Ozempic (semaglutide) tablets 4 mg or 9 mg are indicated: as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes Ozempic injection is indicated: to reduce the risk of major adverse cardiovascular (CV) events (CV death, nonfatal myocardial infarction, or nonfatal stroke) in adults with type 2 diabetes and established CV disease to reduce the risk of sustained eGFR decline, end-stage kidney disease, and cardiovascular death in adults with type 2 diabetes and chronic kidney disease Ozempic tablets are indicated: to reduce the risk of major adverse cardiovascular (CV) events (CV death, nonfatal myocardial infarction, or nonfatal stroke) in adults with type 2 diabetes who are at high risk for these events References: Ozempic injection
Ive seen some patients on the maximal dose have zero side effects and Ive seen other patients on a very minimal dose and have more severe side effects
Mechanistically, the cardioprotective effect of spermine appears to be dependent upon effective elimination of ROS and upregulation of CaSR expression through suppression of the Nrf2-ROS-p53-MuRF1 axis
Supplementary Figure 3
