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That is not speculation
Retatrutide activates GLP-1 receptors (insulin secretion, appetite suppression), GIP receptors (insulin secretion, adipose tissue modulation), and glucagon receptors (increased energy expenditure, hepatic glucose regulation) concurrently
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Because of this specialized absorption process, oral semaglutide must be taken on an empty stomach with a small amount of water, and patients must wait before eating, drinking, or taking other medications
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