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Glutathione synthetase deficiency is an autosomal recessive disorder that was first diagnosed in 1970 in a teenager with a slowly progressive neurologic disorder and markedly elevated excretion of 5-oxoproline in the urine, as well as a history of unexplained jaundice at birth and a history of chronic metabolic acidosis

Defense-related genes encoding osmotin, PR-1b, chitinase, and superoxide dismutase (SOD) enzymes were up-regulated in the transgenic lines as compared to wild-type plants

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Hydroxocobalamin is the preferred B12 formulation in the UK due to its longer duration of action compared to cyanocobalamin