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Based on these findings, the authors concluded that tirzepatide significantly reduced kidney disease progression compared with dulaglutide in patients with T2DM and atherosclerotic cardiovascular disease, lowering the primary composite kidney outcome across all CKD risk subgroups and slowing annual eGFR decline, suggesting a potential additional kidney benefit of dual agonism in this high-risk population.

Tirzepatide is the first drug used for Type 2 diabetes in this age group that has shown sustained clinically-meaningful, BMI-lowering effects, the study authors wrote