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Participants with prediabetes at baseline dropped from 50.7% to 20.3% at the end of the trial
Thereafter, batches of 3 islets per condition were transferred into a 96-well plate containing 200 L KRB per well followed by the addition of 2.8 and 16.7 mM glucose (final concentrations) and the plate was incubated at 37 C for 1 h
In the SURMOUNT-5 trial, tirzepatide produced an average weight reduction of 20.2% (about 50 lbs) over 72 weeks, compared with 13.7% (about 33 lbs) for injectable semaglutide
However, the authors note that substantial weight loss can be accompanied by reductions in lean body mass, underscoring the need for further research into dosing strategies and interventions that preserve muscle while promoting fat loss
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