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Allergic reactions almost always occur early in use, typically with the first few injections
Iron is the only metal in the human body that is toxic if allowed to remain free in the plasma or the fluid compartments of cells
Key sources of ROS include NOXs activation, uncoupled endothelial nitric oxide synthase (eNOS), and mitochondrial dysfunction, all of which are exacerbated by hypertensive stimuli such as Ang II and mechanical shear stress
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