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2 In pernicious anemia, the deficient levels of vitamin B12 are due to the body lacking the intrinsic factor that forms a complex with vitamin B12 which allows absorption into the gut
Whilst we did not find this replicated in our meta-analysis in this particular brain region (nor in any of the individual studies included), nonetheless we did find this difference in the occipital region
Collectively, these studies suggest that enhanced glutamate export and NADPH investment in cancer cells upregulate SLC7A11 levels and enhance dependency on glucose and/or glutamine, though this may be cell line and context dependent ( Figure 2 )
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