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With the introduction of Yurpeak (tirzepatide), we are stepping into obesity care with the same commitment and scale that have defined our efforts in respiratory and chronic therapies

Using Patch-seq, a negative correlation between the hepatocyte nuclear factor 1- (HNF1A) target gene FXYD2 (an inhibitory subunit of the Na + /K + -ATPase) and Na + influx was observed, suggesting a model whereby HNF1A facilitates membrane depolarisation and insulin secretion by upregulating sodium/potassium-transporting ATPase subunit (FXYD2)

I believe this is the group most likely to switch to injectable therapy (Wegovy/Mounjaro), because injections will be seen as a stronger or even a more dependable option

It also plays a critical role in the liver's natural detoxification pathways, helping to process and remove environmental toxins