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PCD represents an evolutionarily conserved, genetically encoded process of active cellular demise that maintains tissue homeostasis through precise responses to molecular signals and microenvironmental cues [14]
Recognizing its potential, Eng patented the discovery in 1993 and later licensed it to Amylin Pharmaceuticals
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To tackle this, several peptide-based GLP-1R agonists have been developed and approved, improving their half-life, efficacy, and bioavailability
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