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The most commonly reported adverse effects in Phase 2 trials were gastrointestinal in nature, including: Nausea (the most frequently reported) Vomiting Diarrhoea Constipation Decreased appetite These effects were generally dose-dependent and most pronounced during dose escalation, typically improving over time

Additionally, residues L339 to L343 in the intracellular loop 3 (ICL3) of the LSN3318839GLP-1(9-36)GLP-1RG s complex, residues F369 to E373 in the extracellular loop 3 (ECL3) of the GLP-1(9-36)GLP-1RG s complex, and residues K130 to S135 in the GLP-1R ECD in these two complexes were poorly resolved and not modeled in the structures

Lower TIMP-2 has been reported in other psychiatric disorders, including MDD (63), and schizophrenia (64)

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