ascendis pharma glp-1 receptor agonist weight management diabetes treatments GLP-1-based therapies for type 2 diabetes: from single, dual and triple agonists to endogenous production and L-cell differentiation | Diabetology & Metabolic Syndrome Oral GLP-1-Based Therapeutics in the

Storgaard H, Cold F, Gluud LL, Vilsboll T, Knop FK

Acta Diabetol (2020) 57(11):131526

Gpxs exist in multiple isoforms, with different cellular localization and different substrate specificity ( 2 O 2 , Prxs seem to be more active, given their higher intracellular concentration and rate constant ( GSH, exploiting the redox-active thiol residue (-SH) of cysteine, exerts its antioxidant function mainly via Gpxs-mediated reactions, which result in peroxide buffering with simultaneous oxidation of GSH to GSSG ( Besides the neutralization of free radicals produced in phase 1 liver metabolism of chemical toxins, GSH also participates in the protection from the resulting electrophilic substrates through the intervention of glutathione-S-transferases (GSTs)

Its how the science works