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Show Sources SOURCES: Photo Credit: iStock/Getty Images StatPearls [Internet] : "Compare and Contrast the Glucagon-Like Peptide-1 Receptor Agonists (GLP1RAs)." Diabetes, Obesity, and Metabolism : "Changes in lean body mass with glucagon-like peptide-1-based therapies and mitigation strategies." Society of Behavioral Medicine: "What are GLP-1 Medications
Slowed colonic transit (the colon) causes constipation
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Genetic and mechanistic work published in 2025 suggests people with lower baseline dopamine function may carry a higher risk for depressive responses on GLP-1 drugs
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