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In their study, human-derived monocytes were treated with either PMA, pharmacologic G6PD inhibitor 6-AN, G6PD-silencing siRNA, siRNA + hyperglycemia, or hyperglycemia alone and then inspected for changes in monocyte polarization without an immunogenic stimulus

In line with these results, also the promoter of miR-34b, a miRNA relevant in BC susceptibility and involved in tumor suppression and cell cycle control, was found hyper-methylated in women exposed to NSW compared to non-exposed controls 232