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Some patients report feeling slightly more energetic after the switch, possibly related to tirzepatides more pronounced effects on glucose stability
Resuming after prolonged interruption may require restarting at a lower dose to re-establish tolerance and minimise gastrointestinal side effects
L-carnitine is also closely related to fat metabolism [9]
By blunting dopamine release and reducing reward signaling in these areas, tirzepatide could theoretically reduce cravings for various substances and even non-substance compulsive behaviors
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