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FOXO4-DRI Safety and Side Effects: What the Evidence Shows (2026) In the published mouse studies, FOXO4-DRI caused no reported side effects: treated animals kept their weight, blood counts, and organ markers while senescent cells were cleared, and the peptide spared healthy cells in culture

A primary focus of research involving this compound is its interaction with the enzyme nicotinamide N-methyltransferase (NNMT)

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Western blot analysis showed that the protein expression of p53-pS15 in the nuclei of keloid fibroblasts was significantly higher than that in normal skin fibroblasts ( p = 0.01