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Berebichez-Fridman, R., & Montero-Olvera, P
The SURPASS-SEMA trial (NCT05583292) compared tirzepatide directly to semaglutide 1.0 mg in type 2 diabetes, showing tirzepatide 10 mg and 15 mg produced superior HbA1c and weight reductions [11]
Retatrutide vs FDA-Approved Alternatives While you wait for retatrutide approval, two FDA-approved alternatives exist: semaglutide (Wegovy, Ozempic) and tirzepatide (Zepbound, Mounjaro)
Phase 3 trials extended to 68 weeks confirmed continued weight loss (28.7% at 68 weeks vs 24.2% at 48 weeks on the 12mg dose)
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