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Both experimental (animals) and clinical studies have shown that many hormones can induce IR including glucocorticoids (GCs), 97 cortisol, 98 growth hormone, 99 and human placental lactogen, 100 which may decrease the insulin-suppressive effects on glucose production and reduce the insulin-stimulated glucose uptake
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Together, these examples underscore the importance of studying metabolic remodeling during human neurodevelopment and emphasize the need for reliable, neuron-specific model systems that can recapitulate early stages of differentiation and bioenergetic specialization
doi: 10.1124/jpet.119.263392 156 Study to Evaluate the Efficacy and Safety of KBP-042 in Patients With Type 2 Diabetes - Full Text View - ClinicalTrials.gov
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