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Mechanisms Underlying Long-Term Synaptic Zinc Plasticity at Mouse Dorsal Cochlear Nucleus Glutamatergic Synapses

[3] DPP-4 is a dipeptidase that selectively binds substrates that contain proline at the P1-position, thus many DPP-4 inhibitors have 5-membered heterocyclic rings that mimic proline, e } : CS1 maint: deprecated archival service (link) Current Topics in Medicinal Chemistry , 7 (6): 597608, doi:10.2174/156802607780090993, PMID 17352680 Current Topics in Medicinal Chemistry , 7 (6): 557568, doi:10.2174/156802607780091028, PMID 17352677 1 2 3 "Dipeptidyl Peptidase-IV Inhibitors: Pharmacological Profile and Clinical Use", Clinical Diabetes , 26 (2): 5357, doi:10.2337/diaclin.26.2.53, retrieved 29 July 2013 Bioorganic & Medicinal Chemistry Letters , 17 (20): 56385642, doi:10.1016/j.bmcl.2007.07.081, PMID 17822893 Bioorganic & Medicinal Chemistry Letters , 15 (21): 47704773, doi:10.1016/j.bmcl.2005.07.026, PMID 16115768 Current Topics in Medicinal Chemistry , 7 (6): 569578, doi:10.2174/156802607780091073, PMID 17352678 1 2 Diabetologia , 50 (1 Supp): S362S363, doi:10.1007/s00125-007-0809-7, PMID 17710465, ProQuest 213848837 (registration required) Journal of Medicinal Chemistry , 50 (10): 22972300, doi:10.1021/jm070104l, PMID 17441705 FDA Continues Review of Takeda's New Drug Application for Alogliptin (SYR-322), a DPP- 4 agent for Type 2 Diabetes , retrieved 29 July 2013

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Diarrhea (24%) Usually transient, lasting 1-3 weeks