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An overview table of included studies is available in the Supplementary Material (S1) and online with options to filter the database ( The table includes information on first author and year of publication (1), paper title (2), whether the study was included in the meta-analysis (3) or systematic review (4), a tag indicating whether ghrelin or GLP-1 was investigated (5), specification of the hormonal assessment and/or manipulation (i.e., whether plasma acyl-, desacyl-, total ghrelin, GLP-1 was measured, which substance was administered (if any)) (6), type of reward phase assessed during fMRI (7), type of reward (e.g., food, money, alcohol) (8), and sample population(s) (9)

These patients were randomized to receive tirzepatide at 5 mg, 10 mg, or 15 mg weekly, or semaglutide 1 mg weekly, while continuing their existing metformin regimen

Furthermore, diuretics and other antihypertensives may potentiate dehydration secondary to GLP-1 RA-induced nausea and vomiting