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some patients report subjective benefits (improved sleep, energy) while others notice no difference compared to placebo-level expectations
There are other options for tendon and ligament injuries such as PRP injections which is safe and effective in certain injuries, these are more appropriate and when combined with rehabilitation often result in favourable outcomes
A 2022 dose-response RCT (Yi et al., Geroscience) at 300/600/900 mg/day raised NAD+ dose-dependently with no safety issues at 60 days
This injection is best used first thing in the morning while you have an empty stomach
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