Seventy percent of study volunteers showed collagen increases compared to untreated controls a response rate significantly higher than that achieved by either comparator compound, both of which are considered first-line clinical options for photoaged skin
A follow-up clinical trial found that a topical crosslinked HA serum applied after fillers, microneedling, or chemical peels was well-tolerated and enhanced skin quality at 14 / 28 days
Sleep quality was assessed via polysomnograms, and the results indicated a significant improvement in sleep quality among the participants receiving DSIP [6]
In it, the researchers administered MOTS-c to mice at various life stages young (two months old), middle-aged (12 months old), and old (22 months old) and saw that subjects at every life stage exhibited improved physical performance in multiple tests, including those assessing motor coordination and running capacity.21 The findings arent dissimilar to a 2023 study in humans, which found that a higher serum MOTS-c concentration correlated with greater muscle mass, force, and power generated during jumping in healthy subjects.22 Reduced inflammation A 2024 study on mature mice points to MOTS-cs potential as a treatment for acute and chronic inflammatory disorders