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Nat Rev Endocrinol 8:495502 Ferrannini E, Baldi S, Frascerra S, Astiarraga B, Heise T, Bizzotto R et al (2016a) Shift to fatty substrate utilization in response to sodium-glucose cotransporter 2 inhibition in subjects without diabetes and patients with type 2 diabetes
Moreover, PGC1 suppressed metastasis of HCC cells by inhibiting the Warburg effect by means of the Wnt/-catenin/PDK1 axis, in a PPAR-dependent manner (Figure 4)
Because that understanding needs to translate into commercial decisions, they also engage directly with innovation and R&D functions around product reformulation, not as a brand exercise but as a response to measurable changes in what their consumers can comfortably consume
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