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72 A KD is usually defined as an isocaloric diet low enough in CHO and high enough in fat to induce significant elevations (0.5 mmol/l in humans) of the ketone bodies (KBs) -hydroxybutyrate and acetoacetate (termed ketosis)

This increase ion concentration interacts with the endoplasmic reticulum, which in turn activates calpain, enhances ROS production and ultimately disrupts cell function

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