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European Heart Journal, 42(25), 2391-2401

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Phase III and large retrospective analyses consistently report a significant reduction in incidence of symptomatic cardiotoxicity with PLD, yet survival benefits remain modest and toxicity simply shifts toward mucocutaneous adverse effects such as palmarplantar erythrodysesthesia and stomatitis [212]

Prima fase della reazione Nella prima fase della reazione, l'acil-CoA sintetasi catalizza il trasferimento del gruppo di adenosina monofosfato (AMP) da una molecola di ATP sull'acido grasso generando un intermedio grasso acil-adenilato e un gruppo pirofosfato (PPi)