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Twelve weeks treatment with the DPP-4 inhibitor, sitagliptin, prevents degradation of peptide YY and improves glucose and non-glucose induced insulin secretion in patients with type 2 diabetes mellitus

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To establish a rigorous threshold for X(PC) sensitivity amidst the inherent variance of high-throughput pooled screening, we applied the following criteria: cell lines were classified as sensitive (hits) if they exhibited a significant ( P 0.5) yielded a signature of 84 genes significantly upregulated in sensitive lines (Extended Data Fig