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The transition to an inflammatory phenotype is known as reactive gliosis, which is characterized by transcriptional, biochemical, metabolic and morphological re-modeling (236)
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Alcohol also decreases intrahepatic T peripheral helper (Tph) cells and T follicular helper (Tfh) cells, lowers IL-21 production by Tfh-like and CD8 + PD-1 + cells, and reduces splenic germinal center B cell areas
These symptoms are most common during the early stages of treatment or when doses are increased, but they often subside as the body adjusts
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