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No dose adjustment is recommended for patients with renal or hepatic impairment, though renal function should be monitored in patients experiencing significant gastrointestinal adverse effects that could lead to dehydration
While one baby in the SUSTAIN 5 trial was born with no known congenital abnormalities after the mother received semaglutide for about 9 weeks, there were two notable cases in the STEP trials
A review of 63 trials involving more than 9,000 people, published in the British Medical Journal and cited by Global News , found that patients on weightloss drugs regained weight at an average of 0.4 kilograms per month after stopping treatment
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