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For persistent GERD symptoms, physicians typically recommend an 8-week PPI trial, followed by step-down to the lowest effective dose
Based on typical drug development timelines (3-5 years from first-in-human trials to approval), an oral dual agonist is unlikely before the late 2020s at the earliest
doi:10.1007/s11934-018-0844-6 Dover JS, Monheit G, Greener M, Pickett A
This triple agonist effect distinguishes it from other drugs such as semaglutide or liraglutide that act primarily via the GLP-1 pathway or in conjunction with one other hormone
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