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The main difference is frequency: tirzepatide is injected once weekly, while semaglutide formulations are dosed once weekly, meaning fewer total injection events per month with tirzepatide therapy
Some patients may experience transient changes in blood pressure, though long-term cardiovascular outcomes studies have generally shown beneficial or neutral effects of GLP-1 receptor agonists on cardiovascular events
You can still get B12 from dairy products, fortified cereals, and fortified non-dairy products if you're vegetarian
Concomitant use of metformin and proton pump inhibitors and vitamin B12 deficiency
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