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BENZODIAZEPINE WITHDRAWAL SYMPTOMS PSYCHOLOGICAL SYMPTOMS Excitability (jumpiness, restlessness) Insomnia, nightmares, other sleep disturbances Increased anxiety, panic attacks Agoraphobia, social phobia Perceptual distortions Depersonalisation, derealisation Hallucinations, misperceptions Depression Obsessions Paranoid thoughts Rage, aggression, irritability Poor memory and concentration Intrusive memories Craving (rare) PHYSICAL SYMPTOMS Headache Pain/stiffness (limbs, back, neck, teeth, jaw) Tingling, numbness, altered sensation (limbs, face, trunk) Weakness (jelly-legs) Fatigue, influenza-like symptoms Muscle twitches, jerks, tics, electric shocks Tremor Dizziness, light-headedness, poor balance Blurred/double vision, sore or dry eyes Tinnitus Hypersensitivity (light, sound, touch, taste, smell) Gastrointestinal symptoms (nausea, vomiting, diarrhoea, constipation, pain, distension, difficulty swallowing) Appetite/weight change Dry mouth, metallic taste, unusual smell Flushing/sweating/palpitations Overbreathing Urinary difficulties/menstrual difficulties Skin rashes, itching Fits (rare) These symptoms have all been described by patients withdrawing from benzodiazepines

So, their long-term safety remains unknown

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The way these small proteins move through and influence such a complex system makes them an intriguing subject of research for many looking to explore long-term brain health