glp 1 receptor agonist agent Chemical structures of GLP-1 antagonists. Representative GLP-1 Receptor Agonists in Solid

Most compounds that target tumor metabolism (methotrexate, 5-fluorouracil) fail to distinguish between tumor tissue and rapidly differentiating epithelial tissue (skin, bone marrow), 4,322 whereas therapies targeting the specific amino acid dependence of tumor cells are cell-selective, such as leukemic blasts that are selectively dependent on Asn, the use of bacterial-derived ASNase in pediatric ALL has significantly improved the cure rate

Mild GI discomfort (stomach upset, diarrhea) is the most commonly reported side effect and usually resolves by taking with food

doi: 10.1099/00221287-131-5-1217 14 Bar-SagiD.RotinD.BatzerA.MandiyanV.SchlessingerJ

doi:10.1542/peds.2008-0317