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Dosing errors and overdose can lead to significant nausea and vomiting that may be prolonged over several days

That is the central message of the SELECT trial (NEJM 2023) the first dedicated cardiovascular outcomes trial of an obesity pharmacotherapy in a non-diabetic population

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Although the findings are not always consistent, changes in the brainstem have been very common, especially structural changes, mainly a decrease in grey or white matter volume in patients, often pronounced in relation to the symptom burden of fatigue, pain and autonomic symptoms