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Pickart and colleagues reported in Nature (1980) that the tripeptide facilitates copper uptake into cultured cells, and potentiometric titration places the GHK-Cu stability constant at log K of approximately 16.4, marginally above the copper transport site of human serum albumin at roughly 16.2

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These studies indicate the potential of utilizing the de novo pathway, a less extensively studied pathway, as a therapeutic strategy for metabolic diseases Barth syndrome is a rare disease caused by mutations in the tafazzin gene encoding for cardiolipin (CL), a phospholipid specific for the mitochondria 303

However, some cancer cells may utilize glutathione to resist treatment