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Dec 2017;58(3):448-457
Insulin gene expression is upregulated in pancreatic -cells after GLP-1R activation, which increases insulin mRNA expression through activation of transcription factors such as pancreatic and duodenal homeobox-1 and cAMP-response element binding protein (Table 1), contributing to an increase in -cell numbers (Tengholm and Gylfe, 2017
They were more common at higher doses and usually occurred while participants were adjusting to treatment
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