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The greatest absolute risk reduction comes from improving very elevated glycaemic levels, and a more modest reduction results from near normalisation of plasma glucose levels [2, 14]
This does not mean the Medical Weight Loss with GLP-1 has stopped working
In 2022, a phase 3 randomized, controlled clinical trial demonstrated that tirzepatide led to a 20 percent reduction in body weight over 72 weeks
GLP-1RAs can suppress foam cell formation by activating GLP-1R signaling induced autophagy [134], reducing ACAT1 expression/activity [93], as well as inhibiting the PKA/CD36 pathway to inhibit ox-LDL uptake [135]
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