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Following this, there is a breakdown of triglycerides, and free fatty acids (FFA) are spilled into the circulation, triggering inflammation and the release of cytokines [Figure 1], mainly interleukin-1 (IL-1) and tumour necrosis factor (TNF) alpha
In contrast to findings with behavioral 20,21,22 and other pharmacological interventions 10,12,13 , the similar mean weight loss achieved with semaglutide 2.4 mg in STEP 5 at weeks 52 and 104 (15.6% and 15.2%, respectively) suggests that, on average, there is minimal weight regain over 104 weeks when once-weekly semaglutide therapy is continued
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