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There arent any large studies that directly compare the two drugs side by side, but clinical trials show theyre both effective when compared to a placebo

We order vitamin B12 and folate testing when a person with Down syndrome we are evaluating has symptoms described above, has a lab abnormality for which follow up testing of vitamin B12 and/or folate is indicated, or the person has a condition in which deficiency is common (e.g., celiac disease)

The severity of gastrointestinal effects typically correlates with dosage and often diminishes as the body adapts to treatment

Mental health considerations are equally important