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Are GLP-1 drugs safe

Clinical studies have shown that patients with type 2 diabetes who use weekly tirzepatide injections experience significant improvements in their HbA1c (a marker of long-term blood glucose control), in addition to substantial weight loss

In a trial of WEGOVY injection in adult patients with type 2 diabetes and body mass index (BMI) greater than or equal to 27 kg/m 2 for weight reduction (Study 3), hypoglycemia (defined as a plasma glucose less than 54 mg/dL) was reported in more patients treated with WEGOVY versus placebo [see Adverse Reactions (6.1)]

The GIPR variant (rs1800437, p.Glu354Gln) was associated with nausea only in people taking tirzepatide