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MarsoSPDanielsGHBrown-FrandsenKKristensenPMannJFENauckMAet alLiraglutide and cardiovascular outcomes in type 2 diabetes
3.5 Respiratory protection In December 2024, tirzepatide received FDA approval for the treatment of moderate-to-severe obstructive sleep apnea (OSA) in obese adults (Yu et al., 2023)
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This review has deliberately distinguished failed biology from failed pharmacology, emphasizing that genuine on-target toxicity, repeated lack of efficacy in well-designed human studies, or insurmountable technical barriers justify abandonment
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