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Glutamatergic neurotransmission also plays a role in addiction, and emerging evidence suggests GLP-1 receptor activation modulates glutamate signaling in reward circuits

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In a similar model, intrathecal injections of exenatide inhibited thermal hyperalgesia and mechanical allodynia by enhancing spinal microglial expression of -endorphins, IL-10 and interleukin 4 (IL-4) [34, 35]

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